Chromopyrrolic
WebMay 1, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; … WebJan 23, 2006 · Chromopyrrolic acid is indicated by filled arrow head, and indole-3-pyruvic acid is indicated by blank arrow heads. Presumably, because of the coexistence of keto …
Chromopyrrolic
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WebAug 19, 2007 · The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one … WebJun 12, 2014 · This compound was named chromopyrrolic acid, and was also detected in the various metabolites produced by the parent strain, although the amount produced was somewhat smaller. The structure of chromopyrrolic acid was closely related to that of violacein and deoxyviolacein. The pyrrole dicarboxylic acid moiety of chromopyrrolic …
WebAbbreviations: P450 or CYP, cytochrome P450; CPA, chromopyrrolic acid. Data deposition: Atomic coordinates and structure factors have been deposited in the Protein Data Bank, www.pdb.org (PDB ID codes 2Z3T and 2Z3U). ¶To whom correspondence may be addressed. E-mail: [email protected] or onaka@ pu-toyama.ac.jp. WebSep 25, 2007 · In the chromopyrrolic acid-soaked structure, residues 1 and 2 and 246–250 (of Chains A and B) and 418–421 (of Chain B) were not included in the model. In this …
WebDichlorochromopyrrolate synthase ( EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3- (7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming). [1] [2] This enzyme catalyses the following chemical reaction 4 2-imino-3- (7-chloroindol-3-yl)propanoate + O 2 Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
Webchromopyrrolic acid (CHEBI:41625) ChEBI > Main CHEBI:41625 - chromopyrrolic acid Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models Formula …
WebSep 1, 2006 · StaP on its own converts chromopyrrolic acid into three aglycone products, K252c, arcyriaflavin A, and 7-hydroxy-K252c; in the presence of StaC, K252c is the predominant product, while the presence of RebC directs formation of arcyriaflavin A. (18)O-Labeling studies indicate that the oxygen(s) of the pyrrolinone and maleimide … cottages on may southern pinesWebchlorination of chromopyrrolic acid or arcyriaflavin was detected when we fed either of these compounds to a S. albus strain expressing rebH. In contrast, coexpression of rebODH or rebOD-CPH yielded chloro and dichloro versions of chromopyrrolic acid (compounds 7 and 10), A S. albus andA ... cottages on loch lomondWebAs a precursor for the synthesis of chromopyrrolic acid by a heme-containing enzyme. As a reactant in the Biginelli-like scaffold syntheses. Packaging. 250, 500 mg. 1, 5 g in poly bottle. Linkage. α-Keto analogue of tryptophan. Safety Information. Pictograms. GHS07. Signal Word. Warning. breath james nestor chaptersWebApr 1, 2009 · The ‘open’ chromopyrrolic acid intermediate must be now converted into a ‘closed’ indolocarbazole aglycone either containing an imide (rebeccamycin-like as in arcyriaflavin A) or an amide (staurosporine-like as in K252c) function at the pyrrole moiety. This requires an enzyme pair that is present in all four clusters (RebC/RebP, StaC ... cottages on lindberg west lafayette indianaWebJun 29, 2024 · 细胞色素P450结构与催化机理_王斌.pdf,闷 讹 缄 纸 酿 养 秩 疆 悸 赊 邯 碧 匆 倍 七 软 桶 靠 赌 银 钦 踌 肢 箭 甲 楔 逗 聊 俱 挽 顽 婉 梗 冯 薄 佐 娩 充 钡 摸 乏 渣 乙 侍 獭 炙 失 奉 械 迄 砸 志 球 巧 峰 井 告 青 殃 颁 惧 长 币 蝗 鸥 造 试 尺 簇 君 斩 糊 伸 棍 滦 祝 格 撇 瞒 骇 前 赠 言 眠 束 乒 愧 ... cottages on petite lakeWebFeb 6, 2013 · Howard-Jones, A.R.; Walsh, C.T. Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD. Biochemistry 2005, 44, 15652–15663. [Google Scholar] Onaka, H. Biosynthesis of indolocarbazole and goadsporin, two different heterocyclic antibiotics produced by … cottages on may southern pines ncWebJul 3, 2014 · This oxidized system tolerates substrates bearing various electron-donating or electron-withdrawing groups. With this methodology, several key intermediates of natural … cottages on mountain creek sandy springs ga