Hirudin
WebThe anticoagulant hirudin is a ~7 kDa acidic protein containing 65 amino acid residues. It occurs naturally in leeches (Hirudo medicinalis). It is the most potent natural inhibitor of … Web24 gen 2024 · The comparison of this gene g17108 (hirudin_2) with all available hirudin sequence may provide insight into the development of a new hirudin with more potent activity. Significantly, although W. pigra and H. medicinalis are both medicinal leeches, the gene copy of bioactive ingredients of W. pigra far exceeds that of H. medicinalis .
Hirudin
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Web16 apr 2024 · Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as “Shuizhi” in traditional Chinese medicine), is the strongest …
WebHirudin may be a particularly useful alternative anticoagulatory agent in patients sensitized to heparin or in patients with hereditary or acquired antithrombin III deficiency. However, whether hirudin is really an effective therapeutic tool and whether it can replace heparin in certain clinical indications can be judged only after extended clinical experience has … Web11 giu 2024 · Natural hirudin, a hirudin isolated from the saliva of bloodsucking leeches, has been used in China for many years and has significant anticoagulant effects 10,11,12.
Web21 mag 2024 · Transcriptome sequencing data (6.5 Gb) of the salivary glands of the haematophagous leech Hirudo nipponia was obtained by using the BGIseq-500 platform. After identification and analysis, one transcript (Unigene5370) was annotated to hirudin HV3 from Hirudo medicinalis with an e-value of 1e-29 and was named hirudin-HN. This … WebTraduzioni in contesto per "hirudin" in inglese-italiano da Reverso Context: Cross-sensitivity to other hirudin products is possible.
WebHirudin is the most potent and specific known inhibitor of thrombin, the enzyme that plays a key regulatory function in hemostasis and blood coagulation. The importance of thrombosis in cardiovascular disease has recently highlighted the limitations of existing antithrombotic drugs and the potential value of direct thrombin inhibition as an effective approach to …
Web25 giu 1993 · The hirudin structure consists of an N-terminal domain folded into a globular unit and a long 17-peptide C-terminal in an extended chain conformation. The N-terminal domain binds at the active-site of thrombin where Ile1' to Tyr3' penetrates to the catalytic triad. The alpha-amino group of Ile1' of hirudin makes a hydrogen bond with OG of ... impact of climate change on permafrostWeb26 ott 2024 · Renal interstitial fibrosis (RIF) is the final common outcome of numerous chronic kidney diseases, contributing to end‑stage renal disease. Hirudin, a thrombin … list tax credit charitiesWebS-Monovette® Hirudin S-Monovette® Hirudin Recombinant Hirudin is a direct thrombin inhibitor and very effectively inhibits blood coagulation (clotting), in vivo and in vitro. Hirudin as an anticoagulant has neither activating nor inhibiting influences on the thrombocytes and presents therefore as the “ideal” anticoagulant. impact of climate change on species wwf 2015WebOver a century has passed since the anticoagulant properties of hirudin were identified. Our understanding of this unique and promising 65 amino acid polypeptide has grown … impact of climate change on polar regionsWebHirudin exemplifies antithrombin anticoagulants. 5 It is a peptide of 65 amino acids with three disulfide bonds and is derived from the saliva of the medicinal leech. Hirudin forms … list tax free statesWebHirudin is a protein substance produced by the salivary glands of medicinal leeches that have a blood anticoagulant property (i.e. Prevent the formation of blood clots by slowing down the blood coagulation process). Hirudin is able to inhibit thrombin, which is an enzyme that catalyzes the hydrolytic transformation of fibrinogen into fibrin ... impact of climate change on russiaWebA plant oleosin was used as a ‘carrier’ for the production of the leech anticoagulant protein, hirudin (variant 2). The oleosin-hirudin fusion protein was expressed and accumulated in seeds. Seed-specific expression of the oleosin-hirudin fusion mRNA was directed via an Arabidopsis oleosin promoter. The fusion protein was correctly targeted to the oil body … impact of climate change on nutrition