Human aggrecan gene
WebVersican (VCAN) is a large extracellular matrix proteoglycan that is expressed in majority human tissues. VCAN is localized on human chromosome 5q14.3, covering a genomic sequence of 109.4 kb. 8 VCAN cDNA contains 15 exons and codes a protein with a molecular mass of >1000 kDa, which belongs to the aggrecan/versican proteoglycan … Web1 Sep 2024 · This literature review leads us to conclude that aggrecan is likely to participate in cardiovascular development, with definitive data from different vertebrates (zebrafish, …
Human aggrecan gene
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WebHuman Aggrecan, amino acids (Val20-Gly675) (Accession# NP_001126), was expressed in 293E cells with a C-terminal 10 His tag and a linker sequence. Molecular Mass This 672 amino acid recombinant protein with a C-terminal His tag has a predicted molecular mass of approximately 74.3 kD. WebIn this study, we prepare a decellularized human nasal septal chondrocyte (NSC)-derived ECM (CHDM), as a natural (N-CHDM) or soluble form (S-CHDM), and investigate their impact on NSCs differentiation. Methods: N-CHDM, S-CHDM were obtained from NSC. To evaluate function of NSC cultured on each substrate, gene expression using …
Webthe aggrecan gene are involved similarly in regulating expres-sion of the gene, potentially in concert with the promoter. Thus, in this study we have cloned and investigated the … Web13 Mar 1998 · Using luciferase reporter constructs driven by the human aggrecan promoter or the cytomegalovirus promoter, the 5'- and 3'-untranslated regions of the human …
Web29 Sep 2016 · In this study, we hypothesized that aggrecanase-associated cartilage degradation could be prevented by blocking the interaction between CXCL12 and its receptor CXCR4. In this study, we used AMD3100 (the specific antagonist of CXCL12/CXCR4 axis) (11.2 mg/kg·day) to block CXCL12/CXCR4 axis.
Web1 Mar 2002 · Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated …
WebSample type: Serum, plasma and cell culture supernates: Cross reacts with: Dog: Product overview : The ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked i spgr fabrics private limitedWebHydrogel-based miR-29b-5p delivery and stem cell recruitment allow cartilage repair in osteoarthritis by suppressing senescence. spgq facebookWebACAN gene aggrecan Normal Function The ACAN gene provides instructions for making the aggrecan protein. Aggrecan is a type of protein known as a proteoglycan, which … spgq formationWeb31 Dec 2008 · Objective To provide a more complete picture of the effect of interleukin-1 beta (IL-1β) on adult human articular chondrocyte gene expression, in contrast to the candidate gene approach. Design Chondrocytes from human knee cartilage were cultured in medium containing IL-1β. Changes in gene expression were analyzed by microarray … spgryfow statutWebThe deduced amino acid sequence of human aggrecan core protein consists of 2415 resides and predicts a signal peptide and domains of G1, IGD, G2, KS, CS-1, CS-2 and … spgr of waterWeb21 Mar 2024 · GeneCards Summary for ACAN Gene ACAN (Aggrecan) is a Protein Coding gene. Diseases associated with ACAN include Short Stature And Advanced Bone Age, … spgrebocin.plWebSample type: Serum, plasma and cell culture supernates: Cross reacts with: Mouse: Product overview : The ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked spgr of toluene