Malat1 and cancer
WebMALAT1 promotes colon cancer cell metastasis by modulating SMC1A expression levels in colon cancer cells. A. Knockdown efficiency of si-MALAT1-1, si-MALAT1-2 and si … WebMALAT1 contributes to the aggressive behavior and worst prognosis of ovarian cancer by sequestering diverse microRNAs. For instance, Lei et al. reported that MALAT1 expression was upregulated in ovarian cancer tissues and cell lines. The silencing of MALAT1 resulted in low cell proliferation of SKOV3 and A2780 cancer cells.
Malat1 and cancer
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Web2 mei 2024 · MALAT1 plays a critical role in tumorigenesis and progression of some cancers and has been considered a potential target in CRPC treatment [ 4, 5 ]. Although … WebThe 3' end of the ~7 kb lncRNA MALAT1 contains an evolutionarily and structurally conserved element for nuclear ... leading to persistent oncogenic activity of MALAT1 in …
WebThe results showed that the expression of MALAT1 was significantly increased in pancreatic cancer tissue. MALAT1 expression also correlated with increased … Web21 jan. 2024 · Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the most abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is …
Web24 feb. 2024 · The lncRNA metastasis-associated lung cancer transcript 1 (MALAT1) is reportedly involved in the occurrence and development of many cancers and serves as a … Web6 dec. 2024 · Results: Studies have shown that aberrant expression of MALAT1 is related to cancer pathophysiology with the potential to be translated clinically and …
Web18 jul. 2024 · MALAT1 expression was further enhanced when PC3 cells were co-cultured with Sost KO osteoblasts and treatment with recombinant Sost down-regulated MALAT1 expression in these cells. Our results suggest that reduced Sost expression in the tumor microenvironment may promote bone metastasis by up-regulating MALAT1 in prostate …
Web26 jul. 2024 · Pulmonary arterial hypertension (PAH) is a debilitating condition of the pulmonary circulatory system that occurs in patients of all ages and if untreated, eventually leads to right heart failure and death. Despite existing medical treatment options that improve survival and quality of life, the disease remains incurable. Thus, there is an … taxis in pitlochryWeb4 feb. 2024 · SNHG1, which is located at chromosome 11q12.3, is overexpressed in several types of tumours, including pancreatic, prostate, non-small-cell lung and BLCA [ 21, 22, 23, 24 ]. It is widely considered an oncogene that promotes cancer proliferation, migration, invasion and tumorigenesis. taxis in pickering north yorkshireWeb8 jul. 2024 · MALAT1 is highly conserved in mammals, is widely expressed in normal human tissues and cells, and has obvious patterns of tissue specific and temporal expression. … the city of utahWeb6 okt. 2024 · Results We identified a key lncRNA (MALAT1) and three key genes (EYA1, WNT5A, and FOXP2) that are closely correlated with the pathogenesis of ALI. LPS stimulation promoted MALAT1 expression and apoptosis and also inhibited HPAEpiC viability. MALAT1 knockdown significantly improved viability and suppressed the … taxis in pickeringWeb27 okt. 2024 · MALAT1 is identified as a nuclear-retained regulatory RNA that can interact with the serine- and arginine-rich (SR) protein splicing factors such as SRSF1, SRSF2, … the city of tyler txWeb6 okt. 2024 · Thus, targeting MALAT1 with antisense oligonucleotides provides a potential therapeutic approach to prevent lung cancer metastasis with MALAT1 serving as both, … the city of waycrossWebRNA MALAT1 for degradation in the nucleus Eleonora Leucci1*, Francesca Patella1,2, Johannes Waage1,3, ... metastasis and survival in early-stage non-small cell lung … taxis in plainfield nj