WebNov 1, 2009 · These guidelines are based on numerous trials showing a benefit for statin therapy both as primary and secondary prevention of cardiovascular disease and mortality (2,,,, –7).Trials like the Collaborative Atorvastatin Diabetes Study (CARDS), proved beyond doubt that patients with type 2 diabetes and other risk factors for CVD should be ... WebFeb 26, 2024 · SECONDARY PREVENTION Based on high-quality evidence from randomized controlled trials (RCTs), high-intensity statin therapy should be instituted with a goal of …
AHA/ASA Stroke Secondary Prevention Guideline: Key …
WebMar 26, 2024 · Statins may prevent recurrent ischemic events after ischemic stroke. Determining which statin to use remains controversial. We aimed to summarize the evidence for the use of statins in secondary prevention for patients with ischemic stroke by comparing benefits and harms of various statins. Methods WebApr 12, 2024 · The secondary outcome was intolerance-related drug discontinuation or dose reduction and low-density lipoprotein cholesterol (LDL-C) level. ... 95% CI, 0.74–1.18; p = 0.570). There was no interaction by age or treatment strategy. Moderate-intensity statin with ezetimibe combination therapy was associated ... Hydroxymethylglutaryl-CoA ... goland clone
Comparison of statins for secondary prevention in patients with ...
WebFeb 10, 2024 · In patients above the age of 65 in secondary prevention trials, statin therapy showed a relative risk reduction of 22% on all-cause mortality and 25% relative risk reduction on stroke. 7 In a recent meta-analysis of 28 randomized controlled trials in patients with an indication for secondary prevention with statins, most patients were included … WebOct 23, 2015 · Statins for Secondary Prevention. Data from the Systolic Hypertension in the Elderly Program (SHEP) trial showed that increased total cholesterol levels were associated with higher risk of coronary artery disease (CAD), suggesting that cholesterol management is an important modifiable risk factor even in patients of advanced age. 1 In the Heart … WebMay 17, 2024 · Statins reduce synthesis of cholesterol by hepatocytes via inhibition of the HMG-CoA reductase. The reduction in intracellular cholesterol increases the expression of LDL-receptors on hepatocytes, thereby increasing the uptake of LDL-C from the blood. The magnitude of LDL-C lowering varies among available statins and is dose-dependent. goland build linux