WebMay 1, 1995 · A peptide toxin, ShK, that blocks voltage-dependent potassium channels was isolated from the whole body extract of the Caribbean sea anemone Stichodactyla helianthus.It competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release at an avian neuromuscular … WebJun 1, 2005 · Chinese hamster ovary (CHO)-K1 cells stably expressing human Kv3.2b (CHO-K1.hKv3.2b) were established and characterized. Stichodactyla helianthus peptide (ShK), isolated from S. helianthus...
Stichodactyla helianthus Neurotoxins - Bio-Syn
WebStichodactyla Helianthus Neurotoxin (ShK) Trifluoroacetate. Supplier: Bachem. These monosubstituted analogs of ShK toxin, a class of K channel blocking peptide toxins … WebApr 9, 2015 · The voltage-gated potassium channel Kv1.3 is an important target for the treatment of autoimmune diseases and asthma. Blockade of Kv1.3 by the sea anemone peptide K +-channel toxin from Stichodactyla helianthus (ShK) inhibits the proliferation of effector memory T lymphocytes and ameliorates autoimmune diseases in animal models. … breakfast near me pickup
Antimicrobial, Antiprotozoal, and Toxic Activities of Cnidarian ...
WebProduct Description ShK-toxin, originally isolated from the sea anemone Stichodactyla helianthus, has been found to inhibit the specific binding of dendrotoxin I to rat brain … WebImmunohistochemical targeting of sea anemone cytolysins on tentacles, mesenteric filaments and isolated nematocysts of Stichodactyla helianthus. Journal of Experimental Zoology, 305A(3): 253-258 Cortés, J. (2009). Zoanthids, sea anemones and corallimorpharians. I. S. Wehrtmann and J. Cortés (eds.). ... WebMay 1, 2005 · Stichodactyla helianthus peptide (ShK), isolated from S. helianthus venom and a known high-affinity blocker of Kv1.1 and Kv1.3 channels, was found to potently inhibit 86 Rb + efflux from CHO-K1.hKv3.2b (IC 50 ∼ 0.6 nM). cost-effective method