WebMay 16, 2024 · Overall accuracy of the ddPCR test. For all studies, the sensitivity and specificity of ddPCR for the detection of T790M mutation in ctDNA ranged from 0.0% to 100.0% and 63.2% to 100.0%, respectively. The concordance between plasma and tissue test was 81.2%, with the PPA being 71.2% and NPA being 90.0%. WebSep 9, 2015 · Costa et al. reported an incidence of de novo T790M of 65% in the EURTAC trial, showing a significant difference in outcome in the erlotinib-treated population (PFS was 15.8 months for those without the concomitant T790M mutation compared with 9.7 months for those with the T790M mutation [p < .0185]) but no difference in the chemotherapy …
T790M - Wikipedia
WebWhen the tissue-based EGFR mutation results were used as the reference, the sensitivity and specificity of the plasma EGFR test for the T790M mutation was 14% (95% CI, 9.5% to 18.7%) and 87% (95% CI, 81.3% to 90.5%), respectively . Timing of plasma and tissue EGFR tests in the paired EGFR cohort WebApr 2, 2024 · T790M, T745M, T523M, T737M Other names NP_005219.2:p.Thr790Met Canonical SPDI NC_000007.14:55181377:C:T Functional consequence - Global minor allele frequency (GMAF) - Allele frequency The Genome Aggregation Database (gnomAD), exomes 0.00003 Trans-Omics for Precision Medicine (TOPMed) 0.00003 Exome … lauren boebert 911 call
Short report: Performance evaluation of the Idylla™
WebWhen the EGFR T790M mutation is not detected by a plasma sample, EGFR mutation testing using tissue samples has traditionally been recommended by several guidelines [12,20,21,22]. However, in this study, due to the location of the lesion or the general condition of the patient, it was not possible to perform a tissue re-biopsy in all patients ... WebJan 3, 2012 · To optimize the T790M detection platform, a pilot test was performed by using EGFR mutant-type plasmids and genomic DNA from normal human peripheral-blood mononuclear cells (PBMCs) and PC-9 and H1975 cell lines for feasibility and specificity testing ( Fig 1 ). WebSep 17, 2024 · The T790M mutation was detected in 46 cases in tDNA analysis, with only one patient presenting with this mutation alone. For an appropriate comparison of the detection rate of T790M mutation, we excluded 22 cases of ctDNA-negative cases. After exclusion, 28 ctDNA-positive cases were revealed T790M mutation by either tDNA or … lauren boebert at state of the union address